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Preventing Attacked Cancer Cells from Repairing Membranes May Enhance Immunotherapy

Pores created in cancer cells by attacking cytotoxic T cells (CTLs) are efficiently repaired by these cancer cells to escape programmed cell death mechanisms. A new study led by scientists at Genentech has found preventing a membrane repair mechanism mediated by the ESCRT pathway may make cancer cells more susceptible to attacks by CTLs and could be therapeutically exploited to increase the efficacy of immunotherapies.