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Hormone Therapy-Induced Metabolomic Shift Linked to Coronary Heart Disease in Menopausal...

Different oral hormone therapy regimens result in large and discordant metabolomic effects that impact the risk for coronary heart disease. 62% of metabolites significantly changed with randomized conjugated equine estrogens (CEE) and 52% with combined CEE and medroxyprogesterone acetate (MPA) treatments.