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Lethal Ovarian Cancer Checked by Dual Attack on Immune Checkpoint, in...

High-grade serous ovarian carcinoma (HGSOC) creates an immunosuppressive tumor microenvironment that renders this form of malignancy insensitivity to checkpoint inhibitor immunotherapies. A new study shows combining an oral inhibitor of a gene that encodes a focal adhesion kinase that is elevated in nearly 70% of patients with HGSOC, together with an antibody that blocks the TIGIT immunoreceptor’s function, generates a significant antitumor response and increased survival time of a mouse model of the lethal cancer.