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Bacterial Sentinel Cells Engineered to Record and Report on Gut Health

Researchers have engineered gut bacteria with data logger functionality to enable them to monitor which genes are active in the bacteria as they traverse the gut. These sentinel microorganisms tested in mice and limited to engineered E. coli in the current study, offer insights that could help develop noninvasive, diagnostic, microbial sensors that could uncover early symptoms of intestinal disease or assess the effect of diet or therapies on health.