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Parallel Genome Editing in Microscopic Worms Maps Regulatory Genomic Elements to...

A group of systems biologists in Berlin have developed parallel genome editing in tiny worms to produce diverse indel mutations in regulatory elements in genomic DNA and a powerful software package, crispr-DART, to analyze the indel mutations following targeted DNA sequencing. Using this new approach, they directly map gene regulatory genotypes to physical and physiological attributes in the worm.

Not Embracing Biological Complexity Is Holding Back Synthetic Biologists

A recent study led by bioengineers at the University of Bristol shows how to simultaneously harnessing gene expression at the levels of both RNA and protein synthesis in living cells can more precisely regulate the switching on and off of genes, opening new avenues for improved biotechnologies.