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Parkinson’s Disease Reversed by Farnesol in Mice

An international team of researchers led by scientists at Johns Hopkins University, School of Medicine, have screened a large library of drugs to find farnesol that inhibits PARIS, a protein that increases in patients with Parkinson’s disease. The authors show farnesylation of PARIS prevented the build up of damaging reactive oxygen species and prevented the loss of dopamine-releasing neurons in the brain in several independent mouse models of Parkinson’s disease.
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