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A new study on mice identifies a potential systemic therapeutic target in the cerebrospinal fluid (CSF) that promotes myelin formation in hippocampal oligodendrocytes, stimulates proliferation of oligodendrocyte progenitor cells, improves neuronal functions, and increases memory recall. The authors investigate the rejuvenating properties of 10-week-old CSF when injected into 18-month-old mice. The study also suggests that routes of drug administration that allow therapeutics to directly access the CSF could be beneficial in treating dementia.
Brain age gap from MRI (magnetic resonance imaging) or FDG (fluorodeoxyglucose positron emission tomography) data is increased in multiple types of dementia, compared to cognitively unimpaired individuals. Therefore, investigators at Mayo Clinic conclude it may be a useful composite biomarker to identify increased risk for pathology or as a marker of disease severity in dementia. The study showed the deep learning model generates accurate age prediction for cognitively normal subjects, with a slightly better performance using an FDG PET input than MRI.
A new study shows amylin-calcitonin receptor (Calcr) signaling in the brain mediates social contact seeking behavior among adult female mice. The study provides molecular evidence in support of a long-held theory that social affiliation among adults evolves from parental care.
A pilot clinical trial conducted by scientists at Durham University in collaboration with Maculume Ltd., provided evidence that self-administration of near-infrared light at 1068 nm wavelength twice daily may improve memory function in healthy, middle-aged people with normal intellectual capacities. The study included 14 healthy people, aged 45 and above who self-deliver six minutes of PBM-T (photobiomodulation therapy) twice daily over four weeks and a placebo group of 13 healthy individuals who wore a dummy PBM-T helmet. The authors said the therapy might have the potential to help people living with dementia and other disorders such as Parkinson’s, traumatic brain injury, and motor neuron disease.
Gene expression studies based on samples from the Hungarian Canine Brain and Tissue Bank established by the research team of the Senior Family Dog Project in 2017, showed the relevance of pet dog biobanking in aging research and identified CDKN2A as a powerful biomarker for aging.
Columbia University researchers showed short-term exposure to fine particulate matter and black carbon in ambient air can reduce GCF (Global Cognitive Function) and MMSE (Mini-Mental State Examination) scores in older men. The investigators also showed that aspirin and other NSAIDs may have a protective role against the effects of air pollution.