Scientists investigate the mystery underlying prolonged and recurrent SARS-CoV-2 positive PCR tests in patients, weeks or months after recovery from an infection. In a much-debated study, MIT investigators demonstrate non-infectious pieces of the virus’ RNA genome can be reverse transcribed into DNA and integrated into human genomic DNA and later transcribed as chimeric human-virus transcripts.
A new study examines the nasal lining in patients with COVID-19 reporting loss of smell and detected SARS-CoV-2 viral particles and inflammation in multiple cell types in the olfactory neuroepithelium, an organized bed of cells that line the nasal cavity. Experimentally infected hamsters also developed a loss of smell linked to the spread of the virus in the nose and nervous system together inflammation.
A new imaging technology called ‘high parameter imaging mass cytometry’ developed through a collaborative effort reveals hitherto unseen details in lung pathology due to several infectious diseases including COVID-19. The new technology shows alveolar epithelial cells are the main targets of SARS-CoV-2 and that age and sex do not affect severe COVID-19 lung pathology.
In an as yet unpublished study presented at the virtual conference ENDO2021, the Endocrine Society's annual meeting, by Manish Raisingani, MD, assistant professor at the Department of Pediatrics at the University of Arkansas for Medical Sciences, children suffering from COVID-19 and adrenal insufficiency are at higher risk of endotracheal intubation, sepsis, and death.
The Novavax investigational COVID-19 vaccine Phase III trial will evaluate the effectiveness, immune response, and safety of NVX-CoV2373. The candidate vaccine is made from non-replicative coronavirus spike protein and a proprietary adjuvant, MatrixMT, that is designed to enhance immune response to the vaccine.