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Dressing Up Noncoding RNA to Dress Down Infections

New research shows modifying noncoding RNA with N6-methyladenosine allows the RNA exosome to recognize a specific noncoding RNA associated with the genomic site that encodes the heavy chain of antibodies, promoting class switch recombination, a process of DNA rearrangement crucial in generating a diverse range of antibodies in B cells. This study highlights the importance of RNA modifications in developing RNA vaccines and therapeutics.