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Type 1 Diabetes Trial Tests Insulin-Secreting Implants Derived from Stem Cells

Two research groups have reported on a multicenter clinical trial that demonstrate insulin secretion from implanted cells in patients with type 1 diabetes. The study grafts pancreatic endoderm cells derived from human pluripotent stem cells (PSCs) under the skin in 26 patients. While the insulin secreted by the implants did not have clinical effects in the patients, the results offer evidence of the possibility of meal-regulated insulin secretion by differentiated stem cells in human patients.