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Brain Rejuvenating Factor Triggers Myelin to Restore Recall in Aged Mice

A new study on mice identifies a potential systemic therapeutic target in the cerebrospinal fluid (CSF) that promotes myelin formation in hippocampal oligodendrocytes, stimulates proliferation of oligodendrocyte progenitor cells, improves neuronal functions, and increases memory recall. The authors investigate the rejuvenating properties of 10-week-old CSF when injected into 18-month-old mice. The study also suggests that routes of drug administration that allow therapeutics to directly access the CSF could be beneficial in treating dementia.