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Stress before Birth Affects Midlife Brain Circuits Differently in the Sexes

Exposure to inflammation promoting cytokines in the womb generated due to maternal stress during pregnancy differentially affects stress and immune regulatory brain circuitry in male and female offspring and retained into midlife. The study demonstrates a need for sex-dependent targets and therapeutics for early therapeutic intervention and prevention in neuropsychiatric disorders such as bipolar disorder, schizophrenia and major depression.

Largest Genome Study to Date Reveals Differences by Sex in Major...

Investigators in a multinational study scanned genomes of nearly 200,000 people to find interactions with genes and sex for schizophrenia, major depressive disorder, and bipolar disorder. These new findings will help identify potential targets for sex-dependent or sex-specific therapeutic interventions creating more effective therapies for both sexes.