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Alzheimer’s Disease Pathology Curbed Using Aromatic Compound in Basil

New research shows a natural compound in basil called fenchol may protect against Alzheimer’s disease pathology. A University of South Florida Health-led team discovered that the aromatic compound fenchol has the same beneficial effect as gut-derived short chain fatty acid (SCFA) metabolites in reducing neurotoxic amyloid-beta in the brain. The authors reported that fenchol, like SCFAs, activates fatty acid receptor 2 (FFAR2) on neurons in the brain, increasing lysosomal and proteasomal activity and decreasing amyloid beta-induced neurotoxicity and neuronal cell death.