Home Tags Antibody diversity

Tag: antibody diversity

Dressing Up Noncoding RNA to Dress Down Infections

New research shows modifying noncoding RNA with N6-methyladenosine allows the RNA exosome to recognize a specific noncoding RNA associated with the genomic site that encodes the heavy chain of antibodies, promoting class switch recombination, a process of DNA rearrangement crucial in generating a diverse range of antibodies in B cells. This study highlights the importance of RNA modifications in developing RNA vaccines and therapeutics.

Aberrant Genome Architectural Organization in Antibody Producing Cells May Cause Cancer

A new study shows abnormalities in packaging of chromosomes in the nuclei of B lymphocytes may play a role in the development of B cell-related blood cancers. The study highlights the role of genomic architecture maintenance for the prevention of cancer and the critical role of DIS3-mediated noncoding RNA processing.