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Tag: age-related macular degeneration

Inhibiting Inflammation Blocks Retinal Death in Animal Models of an Untreatable...

New research from the University of Virginia School of Medicine uncovers a pathological mechanism underlying the degeneration of the retinal pigmented epithelium (RPE) in Geographic Atrophy, an advanced stage of Age-Related Macular Degeneration (AMD). Toxicity induced by complementary DNA of Alu RNA had been implicated in the degeneration of RPE but the mechanism had been unclear. The new study shows Alu cDNA engages the DNA sensor cGAS to induce cytosolic mitochondrial DNA escape, which amplifies cGAS activation, triggering the activation of the inflammasome and RPE degeneration.

HIV Drugs May Be Repurposed for Blindness

A new study reports human cells can synthesize DNA in their cytoplasm and not just in their nucleus or mitochondria. An analysis of nearly 35 million people in multiple cohorts across the United States over 20 years found that FDA-approved anti-HIV drugs that block cytoplasmic DNA synthesis can protect against dry macular degeneration.