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Cancerous Blood Cells Tip the Balance from Death to Growth, New...

Researchers reveal new insights into how acute myeloid leukemia (AML) develops and progresses. Normal isocitrate dehydrogenase enzymes (IDH) are important in cellular metabolism, but mutants produce the carcinogen 2-hydroxyglutarate (2-HG) that causes cancer cells to die at higher concentrations. The team has worked out the threshold at which 2-HG switches from a carcinogen to a cancer-killing agent and the mechanism by which AML cells prevent this switch to keep dividing.
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