February 15, 2018 (Vol. 38, No. 4)

Gyros Protein Technologies

The Gyrolab® Generic Toxicokinetic (TK) kit is a new reagent kit for early-stage biotherapeutic TK studies. The kit allows researchers to more efficiently quantify human therapeutic antibodies (IgG) in automated, nanoliter-scale Gyrolab xP and Gyrolab xPlore™ systems. This kit complements the Gyrolab Generic Pharmacokinetic (PK) kit, introduced in 2017, which is based on the same reagents. The TK kit addresses a higher concentration range compared to the PK kit, making it more suited to toxicokinetic studies. The kits eliminate the need for assay development, as they are supplied in a ready-to-use format, and enable increased productivity as results are generated in just 70 minutes. The two kits cover a combined range of 5 logs, minimizing dilution steps and repeats when performing human IgG quantification in early biotherapeutic development. The kits are designed for use with several species of preclinical animal models, including mouse and cynomolgus monkey. 

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