The next-generation Vanquish Duo UHPLC (ultra-high-pressure liquid chromatography) systems are designed to maximize throughput and return on investment while providing scientists with a robust and comprehensive understanding of their samples. The Vanquish Duo for Dual LC system runs two applications in parallel on a single instrument—whether used for identical analyses to double throughput or for different analyses to obtain deeper sample knowledge. The Vanquish Duo for Tandem LC or LC-MS system is designed to provide maximum sample throughput by eliminating column reconditioning to maximize detector/mass spectrometer utilization. The Vanquish Duo for Inverse Gradient enhances detection for its charged aerosol detection (CAD) technology. Each system in the Vanquish Duo UHPLC family enables scientists to meet different analytical and resource challenges.