The DrySyn Spiral Evaporator is enabling scientists to improve and streamline many aspects of their synthetic organic methods development. The DrySyn Spiral Evaporator is a compact system offering a rapid concentration of even high-boiling solvents such as DMSO, DMF, or water, without the need to heat to high temperatures. Using the evaporator enables scientists to concentrate or dry samples directly from any tube or vial (up to 24 mm neck diameter) in DrySyn reaction vial inserts, up to four samples at a time, all within the footprint of a hotplate. Combining the proven safety benefits of DrySyn with patented spiral plug evaporation technology, this system offers fast and effective parallel evaporation in tubes or vials without solvent bumping, eliminating sample cross-contamination. Other advantages of this system include its ease of use, employment of mild conditions for temperature-sensitive compounds, and efficient recovery of small-quantity samples.