The Refill Revolution is described as an eco-friendly new pipette tip refill system. The system comprises four options: a reusable Box, SingleRefills, StackPacks, and bagged tips. The central Box closes tightly during transport, storage, and autoclaving, and is easily refilled. The SingleRefills are made of 41% less plastic material than the Box, yet are completely sealed to protect tips from contamination during transfer to the Box. StackPacks reduce plastic materials and packaging volume and are anchored to each other to prevent spills. All Refill Revolution tips are certified free of DNA, DNase, and RNase, are CE marked as an in vitro diagnostic product, and meet the ISO 8655-2 testing standard. Some options are additionally sterile and free of PCR inhibitors, ATP, and pyrogens. Standard tips, as well as filtered and low-retention options, are available. All tip trays feature highly resistant laser marking of tip volume, lot number, and expiration date, and they are color-coded for volume.