The LV Edge Packaging System has recently been launched to improve cost efficiency and reduce the supply chain risk of lentiviral production. The company claims the ready-to-transfer system minimizes GMP plasmid cost, process complexity, and supply chain risk by stably integrating viral genes into the host cell. The system was designed to remove the need to transiently transfect three out of the four GMP plasmids. According to the company, the system achieves high harvest titers of over 1E8 TU/mL across multiple chimeric antigen receptor (CAR) transgenes and enables tunable transgene expression in the transduced cell.
