October 15, 2017 (Vol. 37, No. 18)

Irvine Scientific

PRIME-XV® Dendritic Cell Maturation CDM is a chemically defined, animal-component-free medium for the differentiation of monocytes into immature dendritic cells, and subsequent maturation into dendritic cells. Dendritic cells (DCs) are the most potent antigen-presenting cells capable of priming naïve T cells and are, therefore, essential tools in the activation of immune responses to tumors. It is essential for monocyte-derived DCs (Mo-DCs) to maintain their functional capacity to launch antigen-specific immunity, leading to T-cell activation into therapeutic T cells. Serum and undefined components found in animal- or human-derived raw materials can negatively affect this Mo-DC functional capacity. PRIME-XV Dendritic Cell Maturation CDM provides a robust method for the generation of Mo-DCs in chemically-defined culture conditions, thereby maintaining their capacity to induce a T-cell response.