February 1, 2018 (Vol. 38, No. 3)
Silensomes™ HLM products provide researchers a fully characterized premade solution for CYP phenotyping, resulting in more consistent and reliable results. Includes seven cryopreserved human liver microsomes (HLM) pools that are each pretreated with a mechanistic-based inhibitor targeting a single CYP enzyme. This chemical inactivation is mechanism-based and irreversible, giving researchers confidence that their results are accurate and reliable. Each of the seven HLM are packaged as Silensomes™ CYP Phenotyping Kits to include a production-matched control microsome that was treated the same way without the inhibitor. A panel consisting of all seven Silensomes™ HLM with a single matched control is also available.