DNA methylation can offer a look into the mechanics of a disease, or it can add another biomarker to assess during research or diagnosis. However, methylation patterns are difficult to study since they require large sequencing panels, proper preparation of samples, and multiple probes to capture every sequence of interest. The NGS Methylation Detection System by Twist Bioscience is a sample preparation and target enrichment solution to
detect methylated regions in the human genome. The Twist system uses enzyme-based library preparation, provided by New England Biolabs. The company claims the enzymatic library preparation allows 15% more methylated sequences to be detected.