April 1, 2018 (Vol. 38, No. 7)

Pall Biotech

The Stax mAx clarification platform is a robust solution for the economic clarification of monoclonal antibody cell cultures without centrifugation or process additives. The single-use harvesting platform features a four-layer concept and has been optimized to maintain performance as cell density and viability change to minimize the impact of process variability between batches. Media configurations are available in many formats to scale directly from benchtop testing up to large-scale clinical production. The four-layer, two-stage platform features sequentially finer grades to remove aggregates, whole cells, and cell debris. Constructed to retain a small footprint across a wide range of feed streams (with cell densities of up 35 × 106 cells/mL, and feed turbidities of up to around 3,000 NTU), the Stax mAx clarification platform is scalable to support 1,000- to 2,000-L cell culture volumes.

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