March 15, 2018 (Vol. 38, No. 6)
The CadenceTM inline diafiltration (DF) modules for scalable single-pass DF provide repeated downstream dilution and concentration cycles without a recirculation loop. The modules enable fully continuous DF processes in ultrafiltration and DF processing steps and are available in a range of size formats to accommodate various processing volumes, as well as being able to be used in one or more locations of a continuous monoclonal antibody downstream purification process. Pall’s standard T-Series cassettes act as the building blocks for the new Cadence module, which is offered with either Delta regenerated cellulose or OmegaTM polyethersulfone membranes to provide high flux, high selectivity, and low protein-binding characteristics. Users will experience removal factors of ≥3-log, in a scalable, accurate platform that has proven selectivity and low protein-binding attributes.