September 15, 2018 (Vol. 38, No. 16)
Four new antibodies specific for the HIV-1 p24 capsid protein are now available. Recombinant HIV-1 p24 was used as the immunogen (also available for purchase) to generate over 100 antibody candidates. Careful matched-pair screening of mAbs resulted in four clones with sensitive and distinct binding characteristics to both recombinant and native HIV-1 p24. The result is the availability of six matched-pair combinations, and a recombinant protein, that are ready for use in ELISA or point-of-care assay applications. The new reagents are being added to the previously available HIV-1 disease state plasma and patient samples.