September 15, 2018 (Vol. 38, No. 16)


These hepatic non-parenchymal cells (hepatic stellate cells, Kupffer cells, and liver-derived endothelial cells) provide scientists with the building blocks to create more physiologically relevant in vitro models, including co-cultures and 3D cell cultures, for enhanced liver disease research. By creating more sophisticated in vitro culture models that incorporate both hepatocytes and nonparenchymal cells, scientists can improve the translatability of their toxicity testing and pharmacokinetics studies to clinical trials, thus aiding the development of new liver disease treatments.

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