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Multiplex immunofluorescence (mIF) assays offer the advantage of preserving the architectural features of the tumor microenvironment (TME) and revealing the spatial relationships between tumor cells and immune cells that are present. Using an Ultivue 8-plex mIF assay enabled the team to elucidate the T cell phenotypes spatially and quantitively in the context of Adaptimmune’s engineered SPEAR-T cell therapy infiltration within the TME. In this GEN Webinar, our distinguished presenters, Dr. Robyn Broad and Dr. Martin Isabelle, will show us examples of patient baseline and post-infusion biopsies for multiple indications to demonstrate how they uses these analyses to quantify cell densities of subsets of infiltrating immune cells and observe cellular spatial patterns within the tumors.

A live Q&A session followed the presentation, offering a chance to pose questions to our expert panelists.


Robyn Broad
Robyn Broad, PhD
Senior Scientist, Tumor Profiling, Translational Sciences
Martin Isabelle
Martin Isabelle, PhD
Group Leader, Tumor Profiling and Imaging, Translational Sciences