Field-flow fractionation (FFF) is a versatile means of size- based separations, capable of fractionating viral particles, liposomes, and lipid nanoparticles, proteins, and more. The EclipseTM system is the foundation of FFF-MALS, a technique for the separation and characterization of macromolecules and nanoparticles from 1 to 1000 nm in size. The system’s provider claims that Eclipse brings FFF to an entirely new level, combining performance and ease of use. Features include the Dilution Control ModuleTM and the ability to switch between FFF and size-exclusion chromatography separations.