Rare subsets of superpowered immune cells have the ability to execute diverse functions in orchestrating the immune response. These cells can coordinate defenses against a variety of diseases, or conversely, drive inflammation, toxicity, and disease progression. The capacity to decipher dynamic shifts in the proteomes of these superpowered polyfunctional cells provides granular insights that could help develop new cell and gene therapies and biomarkers for diagnosis or assess disease progression and therapeutic efficacy.
This roundtable highlights how scientists are mining single-cell proteomic data to identify and understand dynamic proteomes in high-functioning immune cells and their immune impact. Our expert panel will discuss the development of new cell and immune therapies that target tumors, based on the insights gleaned from proteomic profiles of multifunctional immune cells. In addition to tumor cell heterogeneity, the unique features of the tumor microenvironment, which are playing a critical role in developing effective immunotherapies, are explored by the panel.