Drug discovery is a highly specialized, multidisciplinary effort involving a wide range of scientific disciplines. Over the last few centuries, and particularly in the 20th century, drug discovery has resulted in meaningful, and often life-changing therapeutic advances and increases in quality of life and life span for patients.
Preclinical research methodologies, addressing various novel targets, and the multitude of therapy types stand to revolutionize medical treatment. Whether it is whole genome sequencing, manipulation of individual DNA/RNA sequences through gene engineering, or AI-driven predictive drug discovery, the opportunities to discover novel therapies—including small molecules, biologics, gene, or cell therapies—have never been greater.
This eBook focuses on translational science and discovery partnerships that advance novel therapies through a collective momentum, leveraging efficiencies in drug discovery to accelerate nonclinical research and increase clinical success. We will explore how the development of new modalities can uncover new vistas of possibilities through a collaborative and holistic approach with a strategic partner.
Discovery research covering target and lead identification through to clinical candidate viability is the foundation for drug development and a translational path forward. When small molecule and biotherapeutic drug converge with ADME and pharmacology teams to support a holistic approach; molecule design, assay programs, study selection, data interpretation, and next-step identification improve—accelerating the drug optimization and development cycle.
While small synthetic molecules remain the mainstay of drug development, a new wave of complex biotherapeutics is on the horizon. They play a major role in treating various conditions such as cancer, infectious diseases, allergies, inflammation, and auto-immune diseases, leveraging from the biology learned from other modalities.
In summary, this eBook is designed to highlight the transformational and strategic expertise of Charles River’s Drug Discovery scientists. From basic research to regulatory approval, we have the leading science, range of services, and collaborative approaches you need to accelerate the discovery and development of novel therapies.
