The BIOFLOAT™ 96-well Ultra-Low Adherence cell culture plates were designed specifically for culturing spheroids. The BIOFLOAT surface is anti-adhesive and is said to repel cells of all types, preventing them from attaching to the surface of the plate. According to the company, the BIOFLOAT surface ensures rapid spheroid formation between eight and 24 hours and the chemical composition of the BIOFLOAT surface is very strong, to allow it to withstand multiple washing steps and/or mechanical action from pipetting. Additionally, the BIOFLOAT surface has reportedly proven to be very reliable, even when using difficult cells. Many cell lines and some primary cells have already been successfully tested for spheroid formation on the BIOFLOAT surface.