April 1, 2007 (Vol. 27, No. 7)
Strong Points: Interesting RNA sequences
Weak Points: Too light
Guide RNAs (gRNAs) are trans-acting transcriptional components found in kinetoplastid species. The molecules have roles in RNA editing in these organisms. Trypanosomes, for example, are well-known to undergo extensive editing in which numerous uridines are inserted into RNA after it is made. gRNAs appear to guide the insertion events. At the gRNA database, one can find a table listing the known gRNA sequences, as well as a list of relevant references. Unfortunately, the gRNA Database site lacks breadth. I had to Google gRNA, for example, to find a good description of it, as one wasn’t to be found at the site. To be fair, this is the website of a lab, and one shouldn’t expect it to span giant dimensions, but descriptions, at a minimum, need to be considered.