Vitamin B3 Analogue May Boost Cancer Immunotherapy

Stressors encountered in the tumor microenvironment—chronic stimulation by cancer antigens, PD-1 signaling, and the metabolic stress of nutrient and oxygen deprivation—can drive tumor-infiltrating T cells to exhaustion. Preventing or reversing this exhaustion may be possible with a nutritional approach that counters an underlying mechanism, the accumulation of dysfunctional mitochondria.