Transcriptomics Reveals Liver Genes and Circadian Clock Crosstalk in Time and Space

Scientists have uncovered that the expression of many liver genes is dually regulated, spatially and temporally. The new study uses innovative statistical approaches to analyze RNA sequencing and smFISH data to reveal the expression patterns of 5,000 genes in individual liver cells across a 24-hour period and modeled how the circadian clock and liver functions crosstalk in sync with the feeding-fasting cycle.