Swallowing Difficulties May Be Caused by Misfiring Neurons

Using a mouse model of DiGeorge syndrome, researchers uncovered that the motor neurons that directly control the tongue muscles were firing spontaneously, out of sync with the mechanisms that should control their activity. These findings provide a foundation for understanding that misfiring neurons—that control key parts of the mouth and tongue—may be creating swallowing difficulties in children with neurodevelopmental disorders.