Studying Activity of “Deprivation Neurons” Could Help to Explain Why Dieting Is So Hard

By studying an engineered mouse model in which certain neurons can be switched on and off, BDIMC scientists have uncovered how a lack of calories activates AGRP nerve cells in the hypothalamus, causing the unpleasant feelings of hunger. The results indicate that dieting is hard because when we diet we are perpetually stuck with this aversive feeling, which can be stopped by eating, to reduce AGRP neuron activity and alleviate the unpleasant feelings.