A new large-scale genome-wide association study (GWAS) from investigators at Massachusetts General Hospital (MGH) and the University of Exeter Medical School has uncovered some interesting genetic loci associated with sleep duration. This same team previously reported finding gene sites associated with insomnia risk and chronotype—the tendency to be an early riser or a “night owl.” Findings from the new study—published recently in Nature Communications through an article titled “Genome-wide association study identifies genetic loci for self-reported habitual sleep duration supported by accelerometer-derived estimates—identified 76 new gene regions associated with sleep duration.
It is well understood that regularly getting adequate sleep—7 to 8 hours per night—is important to health, and both insufficient sleep—6 or fewer hours—and excessive sleep—9 hours or more—have been linked to significant health problems. Family studies have suggested that from 10–40% of the variation in sleep duration may be inherited, and previous genetic studies have associated variants in two gene regions with sleep duration.
“While we spend about a third of our life asleep, we have little knowledge of the specific genes and pathways that regulate the amount of sleep people get,” explained co-lead study investigator Hassan Saeed Dashti, PhD, research fellow in medicine at the MGH Center for Genomic Medicine. “Our study suggests that many of the genes important for sleep in animal models may also influence sleep in humans and opens the door to better understanding the function and regulation of sleep.”
In the current study, the largest of its kind to address sleep duration, analyzed genetic data from more than 446,000 participants in the U.K. Biobank who self-reported the amount of sleep they typically received. This GWAS identified 78 gene regions—including the two previously identified—as associated with sleep duration. While carrying a single gene variant influenced the average amount of sleep by only a minute, participants carrying the largest number of duration-increasing variants reported an average of 22 more minutes of sleep, compared with those with the fewest, which is comparable to other well-recognized factors that influence sleep duration.
“Finding 78 areas of the genome that influence habitual sleep duration represents a huge leap forward in our understanding of the mechanisms behind why some people need more sleep than others,” noted co-lead author Samuel Jones, PhD, a research fellow at the University of Exeter Medical School. “As part of a wider body of work, our discoveries have the potential to aid the discovery of new treatments for sleep and sleep-related disorders.”
To confirm the accuracy of findings based on self-reported sleep duration, the researchers tested the 78 duration-associated variants in a subgroup of participants who had worn motion-detecting devices called accelerometers for up to a week. Not only were those gene regions supported by objective measurement of sleep duration, but this analysis was also able to associate duration-related variants with factors such as sleep efficiency, instances of waking up during the night and daytime inactivity.
Only a few of the gene regions identified in this study overlap with those identified in the group’s previous studies of insomnia and chronotype. The sites identified in this study showed consistent effects with a previous GWAS of more than 47,000 adults but limited consistency with another GWAS of sleep duration among more than 10,500 children and adolescents, which supports research suggesting that the genetics of sleep duration may be different in children than in adults.
Since both shorter- and longer-than-average sleep duration have been associated with health problems, the team conducted separate GWASs for participants who reported short or long sleep duration. Those studies identified additional genes not identified in the larger group analysis that contributed to either longer or shorter sleep duration. The researchers also found shared genetic links between both short and long sleep duration and factors such as higher levels of body fat, depression symptoms, and fewer years of schooling, implying negative effects from both too little and too much sleep. In addition, short sleep duration was genetically linked with traits such as insomnia and smoking, while long-duration variants were linked with schizophrenia, type 2 diabetes, and coronary artery disease.
“While follow-up studies are required to clarify the functional impact of these variants, the associated genes are known to play a role in brain development and in the transmission of signals between neurons,” concluded senior study investigator Richa Saxena, PhD, assistant professor at Harvard Medical School and member of the MGH Center for Genomic Medicine. “These findings suggest themes for future investigations of the sleep-wake control centers of the brain that will help us tease apart mechanisms of disordered sleep and help understand each person’s natural set point for refreshing sleep.”
