Scientists Identify Mechanism Linking Exercise with Bone Strength and Immunity

Scientists at the Children’s Medical Center Research Institute at UT Southwestern (CRI) identified a new mechanism by which exercise strengthens bones and immune function. The studies collectively indicate that forces created from walking or running are transmitted from bone surfaces along arteriolar blood vessels into the marrow inside bones. The bone-forming cells that line the outside of the arterioles sense these forces, proliferate, and secrete a growth factor that increases production of immune system cells.