Retroviral Elements Could Be Exploited to Fight Esophageal Cancer

In esophageal cancer, the Sox2 gene may be overexpressed, promoting chromatin remodeling and helping to promote the activation of various cancer-causing genes. In addition, Sox2 may induce the expression of endogenous retroviral elements, leading to the accumulation of double-stranded RNAs, which could provoke an immune response, provided ADAR1, an RNA-degrading enzyme, is inhibited.