Novel Antifungal Approach Targets Fat Production in Fungi

Scientists have identified a class of compounds that effectively inhibit fungal growth by targeting fungal fatty acid metabolism. The authors tested a library of small molecule compounds against fungal fatty acid synthase and desaturase enzymes that are essential for the growth and virulence of human fungal pathogens and identified 16 compounds that inhibited fatty acid desaturase. The compounds were effective against drug-resistant strains of several infectious fungi and showed little toxicity to mammalian cells.