Study published in Geome Research also confirms genetic marker linked previously identified in Caucasians.
Researchers identified a new genetic mutation that is associated with prostate cancer in African Americans and also confirmed another mutation previously found in Caucasians.
In this study, scientists analyzed 8q24 region of chromosome 8 highlighted by the earlier studies done on Caucasian men. This time, however, they searched for genetic differences between 490 African American men who had been diagnosed with prostate cancer at Howard University Hospital and 567 African American men without cancer.
The investigators were able to replicate the linkage of rs16901979, one of the markers identified in a previous study. They also found a new genetic marker, known as rs7008482, that they say was even more strongly associated with prostate cancer in African Americans. This marker was located within a gene that is involved in DNA replication, recombination, and repair.
The study was conducted by the University of Chicago and the Translational Genomics Research Institute. The paper is published online and will appear in the December issue of Genome Research.