MicroRNA in Obese Mothers, Grandmothers Passes Increased Liver Cancer Risk to Multiple Generations of Offspring

Researchers in China have identified a microRNA in obese mouse mothers that is passed on to their pups, increasing the risk of hepatocellular carcinoma developing in offspring, down multiple generations. The study found that the maternal microRNA, miR-27a-3p, acted to increase the risk of liver cancer in offspring by regulating two genes, Acsl1 and Aldh2. Analysis of human liver tumor samples also found that miR-27a-3p was negatively correlated with Ascl1 and Aldh2.