Microchip Biotechnologies is collaborating with Stanford University to develop a front-end, microfluidic-based sample-preparation system to generate template libraries for superscalar pyrosequencing. The goal is to automate the complex, multistep upstream template production using MBI’s microscale on-chip valves (MOV™).

Pyrosequencing relies on the bioluminometric real-time detection of inorganic pyrophosphate that is released on successful incorporation of nucleotides during DNA synthesis.

“By integrating and automating the upstream sample processing, it is envisioned that a mammalian genome can be sequenced in a day,” according to Mostafa Ronaghi, Ph.D., senior research scientist and the principal investigator of the project at Stanford.

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