Memory of Centromere Encoded in Epigenome One Generation Deep

Two teams of researchers at the University of Geneva (UNIGE) have discovered that the location of the centromere—a specific chromosomal site that holds duplicated chromosomes together and plays an important role in cell division—is transmitted between two generations through epigenetic mechanisms. Using specific mutants in a microscopic worm generated using CRIPSR technology, the researchers show that once the centromere is defined, its location is transmitted to the next generation independent of the DNA that guides the centromere defining protein CENP-A, leading the authors to conclude an epigenetic memory mechanism.