Understanding how the body responds to excess weight and body fat is essential for combating the numerous ill effects of obesity. With that in mind, a team of researchers led by investigators at the University of Texas Southwestern (UTSW) set out to try and explain the “obesity paradox,” a phenomenon in which obese individuals have better short- and medium-term cardiovascular disease prognoses compared with those who are lean, but with ultimately worse long-term outcomes. Amazingly, the researchers found that a stress signal received by the heart from fat could help protect against cardiac damage induced by obesity. Data from the new study was published recently in Cell Metabolism through an article titled, “Extracellular vesicle-based interorgan transport of mitochondria from energetically stressed adipocytes.”

“The mechanism we have identified here could be one of many that protect the heart in obesity,” explained senior study investigator Philipp Scherer, PhD, a professor of internal medicine and cell biology at UTSW who has long studied fat metabolism.

Lead study investigator Clair Crewe, PhD, an assistant instructor of internal medicine at UTSW, explained that the metabolic stress of obesity gradually makes fat tissue dysfunctional, causing its mitochondria—the cellular organelles that generate energy—to shrink and die. Eventually, this unhealthy fat loses the ability to store lipids generated by excess calories in food, poisoning other organs through an effect called lipotoxicity. Some organs, including the heart, appear to mount a preemptive defense to protect against lipotoxicity. But how the heart senses fat’s dysfunctional state has been unknown.

The research team used a genetic technique to speed the loss of mitochondrial mass and function in mice in their study. When these animals ate a high-fat diet and became obese, the researchers found that the rodents’ fat cells sent out extracellular vesicles filled with small pieces of dying mitochondria. Some of these mitochondrial snippets traveled through the bloodstream to the heart, triggering oxidative stress, a state in which cells generate harmful free radicals.

“We have found that adipocytes respond to mitochondrial stress by rapidly and robustly releasing small extracellular vesicles (sEVs),” the authors wrote. “These sEVs contain respiration-competent, but oxidatively damaged mitochondrial particles, which enter circulation and are taken up by cardiomyocytes, where they trigger a burst of ROS. The result is compensatory antioxidant signaling in the heart that protects cardiomyocytes from acute oxidative stress, consistent with a preconditioning paradigm. As such, a single injection of sEVs from energetically stressed adipocytes limits cardiac ischemia/reperfusion injury in mice.”

To counteract this stress, heart cells produce a flood of protective antioxidant molecules. This protective backlash was so strong that when the scientists injected mice with extracellular vesicles filled with mitochondrial snippets and later induced a heart attack, the animals had significantly less damage to their hearts compared with mice that didn’t receive an injection.

Further research using fat tissue sampled from obese patients showed that these cells also release mitochondria-filled extracellular vesicles, Crewe said, suggesting that the effects observed in mice also take place in humans.

Eventually, she explained, the heart and other organs in obese individuals become overwhelmed by lipotoxic effects, leading to many of obesity’s comorbidities. However, learning how to artificially generate the protective mechanism identified in this study could lead to new ways to buffer obesity’s negative consequences. This knowledge could even suggest strategies to protect the heart against damage in lean individuals as well.

“By better understanding the distress signal from fat,” Crew noted, “we may be able to harness the mechanism to improve heart health in obese and non-obese individuals alike.”

“This study provides the first description of functional mitochondrial transfer between tissues and the first vertebrate example of “inter-organ mitohormesis,” the authors concluded. “Thus, these seemingly toxic adipocyte sEVs may provide a physiological avenue of potent cardioprotection against the inevitable lipotoxic or ischemic stresses elicited by obesity.”

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