Linear amplification technology produces a nonexponential amplification from relatively small amounts of RNA.
Enzo Biochem received a license to a comprehensive non-PCR-based amplification technology that allows researchers to increase amplification from relatively small RNA samples in gene expression studies. This licence with LBS Technologies includes rights to six U.S. patents, which are all related to this technology.
Unlike exponential amplification techniques, such as RT-PCR, linear amplification technology maintains the relative ratios of the starting RNA population, thereby allowing for more accurate expression profile studies. This technique involves a series of enzymatic reactions that produce a nonexponential amplification of RNA from relatively small amounts of RNA extracted from biopsies, laser-capture microdissection, and other tissue sources where the sample size is limited.