Crohn’s Disease Treatment Studied in Mouse Model and Patient-Derived T Cells

A University of Alabama at Birmingham (UAB)-led research team has demonstrated a potential preventive treatment for Crohn’s disease, both in a mouse model and through the use of immune-reactive T cells from patients with the inflammatory bowel disease. The researchers devised a triple-punch treatment to remove T memory cells and increase the number of T regulatory cells. This strategy prevented colitis in a T cell transfer mouse model, and similar inhibitory effects were also seen on immune-reactive CD4+ T cells isolated from Crohn’s disease patient blood samples.