Common Antidepressant Could Represent First Disease-Modifying Treatment for Osteoarthritis

Research headed by scientists at Penn State College of Medicine found that the antidepressant paroxetine can halt the progression of osteoarthritis, and regenerate damaged cartilage in the joints of mice. The study found that paroxetine inhibited the enzyme GRK2, which was overexpressed in osteoarthritis in human tissue samples, and mouse models. Using paroxetine to inhibit GRK2 slowed the development of osteoarthritis in mice, and promoted cartilage healing in damaged joints.